Effects of PARP Inhibitor 3-Aminobenzamide on Impaired Mesenteric Blood Flow and Organ Injury in CLP-Induced Septic Shock Model

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Ertac-Serdar S., ATİLLA P., İSKİT A. B.

JOURNAL OF CRITICAL & INTENSIVE CARE, vol.13, no.1, pp.32-42, 2022 (ESCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 13 Issue: 1
  • Publication Date: 2022
  • Doi Number: 10.37678/dcybd.2022.2942
  • Journal Name: JOURNAL OF CRITICAL & INTENSIVE CARE
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.32-42
  • Keywords: 3-Aminobenzamide, PARP, septic shock, gender difference, anesthetized mice, sepsis, ACTIVATED PROTEIN-KINASE, ADP-RIBOSE POLYMERASE-1, NITRIC-OXIDE, POLY(ADP-RIBOSE) SYNTHETASE, POTENT INHIBITOR, CECAL LIGATION, IN-VITRO, APOPTOSIS, DYSFUNCTION, RESISTANCE
  • Hacettepe University Affiliated: Yes

Abstract

Objective: In various pathophysiological conditions, including septic shock, reactive oxidants cause DNA strand breakage and subsequent activation of the nuclear enzyme poly (ADP ribose) polymerase (PARP). Activation of PARP results in cellular dysfunction. We investigated the 3-Aminobenzamide (3-AB), one of the pure PARP-1 inhibitor, on mesenteric blood flow and organ injury (lung, liver, spleen) in a murine caecal ligation and puncture (CLP) model of septic shock in both gender.