Effects of PARP Inhibitor 3-Aminobenzamide on Impaired Mesenteric Blood Flow and Organ Injury in CLP-Induced Septic Shock Model

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Ertac-Serdar S., ATİLLA P., İSKİT A. B.

JOURNAL OF CRITICAL & INTENSIVE CARE, cilt.13, sa.1, ss.32-42, 2022 (ESCI) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 13 Sayı: 1
  • Basım Tarihi: 2022
  • Doi Numarası: 10.37678/dcybd.2022.2942
  • Dergi Adı: JOURNAL OF CRITICAL & INTENSIVE CARE
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.32-42
  • Anahtar Kelimeler: 3-Aminobenzamide, PARP, septic shock, gender difference, anesthetized mice, sepsis, ACTIVATED PROTEIN-KINASE, ADP-RIBOSE POLYMERASE-1, NITRIC-OXIDE, POLY(ADP-RIBOSE) SYNTHETASE, POTENT INHIBITOR, CECAL LIGATION, IN-VITRO, APOPTOSIS, DYSFUNCTION, RESISTANCE
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Objective: In various pathophysiological conditions, including septic shock, reactive oxidants cause DNA strand breakage and subsequent activation of the nuclear enzyme poly (ADP ribose) polymerase (PARP). Activation of PARP results in cellular dysfunction. We investigated the 3-Aminobenzamide (3-AB), one of the pure PARP-1 inhibitor, on mesenteric blood flow and organ injury (lung, liver, spleen) in a murine caecal ligation and puncture (CLP) model of septic shock in both gender.