Treatment of a Tongue Lymphangioma With Sirolimus after Failure of Surgical Resection and Propranolol


AKYÜZ C., ATAS E., VARAN A.

PEDIATRIC BLOOD & CANCER, cilt.61, sa.5, ss.931-932, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 61 Sayı: 5
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1002/pbc.24866
  • Dergi Adı: PEDIATRIC BLOOD & CANCER
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.931-932
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Lymphangiomas of the tongue are rare, and their treatment is problematic. A 10 year-old patient with tongue lymphangioma who was previously treated with surgery and propranolol with no response was treated with sirolimus in our department. We used sirolimus with a dose of 1.6mg/m(2)/day. After 3 months of treatment, the mass had decreased by more than 60%. We continued the treatment for 1 year with a maximum response of 70% decrease in mass. Disease remained stable 6 months after stopping therapy, the latest time of follow-up. Sirolimus appears to be effective in lymphangioma but requires further study. Pediatr Blood Cancer 2014;61:931-932. (c) 2013 Wiley Periodicals, Inc.