Treatment of a Tongue Lymphangioma With Sirolimus after Failure of Surgical Resection and Propranolol

AKYÜZ C., ATAS E., VARAN A.

PEDIATRIC BLOOD & CANCER, vol.61, no.5, pp.931-932, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 61 Issue: 5
  • Publication Date: 2014
  • Doi Number: 10.1002/pbc.24866
  • Journal Name: PEDIATRIC BLOOD & CANCER
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.931-932
  • Hacettepe University Affiliated: Yes

Abstract

Lymphangiomas of the tongue are rare, and their treatment is problematic. A 10 year-old patient with tongue lymphangioma who was previously treated with surgery and propranolol with no response was treated with sirolimus in our department. We used sirolimus with a dose of 1.6mg/m(2)/day. After 3 months of treatment, the mass had decreased by more than 60%. We continued the treatment for 1 year with a maximum response of 70% decrease in mass. Disease remained stable 6 months after stopping therapy, the latest time of follow-up. Sirolimus appears to be effective in lymphangioma but requires further study. Pediatr Blood Cancer 2014;61:931-932. (c) 2013 Wiley Periodicals, Inc.