Validation of Patient-Reported Outcomes Measurement Information System (PROMIS) Pediatric Measures for Children With Chronic Nonbacterial Osteomyelitis

Eckert, Mary; Wu, Eveline; Oliver, Melissa; Scheck, Joshua; Lapidus, Sivia; KAYA AKCA, ÜMMÜŞEN; Yasin, Shima; Lenert, Aleksander; Stern, Sara; Insalaco, Antonella; Pardeo, Manuela; Simonini, Gabriele; Marrani, Edoardo; Wang, Xing; Huang, Bin; Kovalick, Leonard; Rosenwasser, Natalie; Balay-Destrude, Erin; Casselman, Gabriel; Liau, Adriel; Klein, Ava; Shao, Yurong; Yang, Claire; Briggs, Molly; Mueller, Ethan; Deng, Emily; Trunnell, Paige; Hamilton, Iris; Machrone, Elise; Mosa, Doaa; Tucker, Lori; Girschick, Hermann; Laxer, Ronald; Tiller, Georgina; Akikusa, Jonathan; Hedrich, Christian; Onel, Karen; Dedeoglu, Fatma; Twilt, Marinka; Ozen, SEZA; Ferguson, Polly; Schanberg, Laura; Reeve, Bryce; Zhao, Yongdong

doi:10.1002/acr.80146

Validation of Patient-Reported Outcomes Measurement Information System (PROMIS) Pediatric Measures for Children With Chronic Nonbacterial Osteomyelitis

Eckert M. M., Wu E. Y., Oliver M., Scheck J., Lapidus S., KAYA AKCA Ü., ...Daha Fazla

Arthritis Care and Research, 2026 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Basım Tarihi: 2026
Doi Numarası: 10.1002/acr.80146
Dergi Adı: Arthritis Care and Research
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CINAHL, EMBASE, MEDLINE, Natural Science Collection (ProQuest), Biological Science Database (ProQuest), Health Research Premium Collection (ProQuest), Materials Science & Engineering Collection (ProQuest), Technology Collection (ProQuest)
Hacettepe Üniversitesi Adresli: Evet

Özet

Objective: To assess the validity of the Patient-Reported Outcomes Measurement Information System (PROMIS) Pediatric measures in patients with chronic nonbacterial osteomyelitis (CNO). Methods: Within the longitudinal patient registry of CNO, English-speaking patients aged 8 years and older self-reported PROMIS Pediatric measures of fatigue, pain interference (PI), pain behavior (PB), mobility, upper extremity (UE), physical activity (PA), and strength impact (SI), and external validation measures. Log-transformed linear mixed-effects models with random patient intercepts were used to assess PROMIS T-score changes. Wilcoxon signed-rank test was performed to determine the PROMIS T-score changes among the improved, worsened, and unchanged groups. Spearman rank correlation test determined the relationship of PROMIS T-scores with disease status reported by patients/families. Results: More than 1,000 clinical visits from 184 patients included PROMIS Pediatric measures entries. All PROMIS T-scores correlated significantly (P < 0.01) with patient-reported variables and physician global assessment (PHGA). The correlation between function and mobility, PB, and PI was good (r = 0.4–0.6). The correlation of patient-reported disease status was strong with PHGA (r = 0.75); moderate with mobility, PB, and PI; and weak with fatigue, SI, UE, and PA. The changes of PROMIS T-scores over time for mobility, PB, PA, and PI compared with the self-reported status change were significant (P < 0.05). After effective treatment, when clinical disease activity score improved by at least three points (n = 18), the change of PROMIS T-scores for mobility, PB, PI, and UE were significant (P < 0.05). Conclusion: This study provided evidence supporting the use of PROMIS Pediatric mobility, PB, and PI measures for CNO clinical disease monitoring.