Loss of heterozygosity in the VNTR region of intron 1 of p53 in two retinoblastoma cases

Emre S., Sungur A., Bilgic S., Buyukpamukcu M., Gunalp I., Ozguc M.

PEDIATRIC HEMATOLOGY AND ONCOLOGY, cilt.13, sa.3, ss.253-256, 1996 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 13 Sayı: 3
  • Basım Tarihi: 1996
  • Doi Numarası: 10.3109/08880019609030824
  • Dergi Adı: PEDIATRIC HEMATOLOGY AND ONCOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.253-256
  • Anahtar Kelimeler: loss of heterozygosity, p53, retinoblastoma primary tumor, VNTR, GENE
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Loss of heterozygosity (LOH) was studied in 10 primary retinoblastoma tumors in the VNTR region of intron 1 in p53 gene by the polymerase chain reaction. To our knowledge mutations have not been reported in the p53 gene in retinoblastoma primary tumours. Heterozygosity was found at this region in 5 of 10 cases. Two pathology paraffin block samples showed loss of heterozygosity.