Loss of heterozygosity in the VNTR region of intron 1 of p53 in two retinoblastoma cases

Emre, SERAP; Sungur, A; Bilgic, S; Buyukpamukcu, M; Gunalp, I; Ozguc, M

doi:10.3109/08880019609030824

Loss of heterozygosity in the VNTR region of intron 1 of p53 in two retinoblastoma cases

Emre S., Sungur A., Bilgic S., Buyukpamukcu M., Gunalp I., Ozguc M.

PEDIATRIC HEMATOLOGY AND ONCOLOGY, vol.13, no.3, pp.253-256, 1996 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 13 Issue: 3
Publication Date: 1996
Doi Number: 10.3109/08880019609030824
Journal Name: PEDIATRIC HEMATOLOGY AND ONCOLOGY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.253-256
Keywords: loss of heterozygosity, p53, retinoblastoma primary tumor, VNTR, GENE
Hacettepe University Affiliated: Yes

Abstract

Loss of heterozygosity (LOH) was studied in 10 primary retinoblastoma tumors in the VNTR region of intron 1 in p53 gene by the polymerase chain reaction. To our knowledge mutations have not been reported in the p53 gene in retinoblastoma primary tumours. Heterozygosity was found at this region in 5 of 10 cases. Two pathology paraffin block samples showed loss of heterozygosity.