5-Androstene-3 beta,17 beta-diol Promotes Recovery of Immature Hematopoietic Cells Following Myelosuppressive Radiation and Synergizes With Thrombopoietin

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Aerts-Kaya F. S. F., Visser T. P., Arshad S., Frincke J., Stickney D. R., Reading C. L., ...More

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, vol.84, no.3, 2012 (SCI-Expanded) identifier identifier identifier


Purpose: 5-Androstene-3 beta,17 beta-diol (5-AED) stimulates recovery of hematopoiesis after exposure to radiation. To elucidate its cellular targets, the effects of 5-AED alone and in combination with (pegylated) granulocyte colony-stimulating factor and thrombopoietin (TPO) on immature hematopoietic progenitor cells were evaluated following total body irradiation.