5-Androstene-3 beta,17 beta-diol Promotes Recovery of Immature Hematopoietic Cells Following Myelosuppressive Radiation and Synergizes With Thrombopoietin

Aerts-Kaya, FATİMA; Visser, Trudi; Arshad, Shazia; Frincke, James; Stickney, Dwight; Reading, Chris; Wagemaker, Gerard

doi:10.1016/j.ijrobp.2012.04.021

5-Androstene-3 beta,17 beta-diol Promotes Recovery of Immature Hematopoietic Cells Following Myelosuppressive Radiation and Synergizes With Thrombopoietin

Aerts-Kaya F. S. F., Visser T. P., Arshad S., Frincke J., Stickney D. R., Reading C. L., ...Daha Fazla

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, cilt.84, sa.3, 2012 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 84 Sayı: 3
Basım Tarihi: 2012
Doi Numarası: 10.1016/j.ijrobp.2012.04.021
Dergi Adı: INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
Hacettepe Üniversitesi Adresli: Evet

Özet

Purpose: 5-Androstene-3 beta,17 beta-diol (5-AED) stimulates recovery of hematopoiesis after exposure to radiation. To elucidate its cellular targets, the effects of 5-AED alone and in combination with (pegylated) granulocyte colony-stimulating factor and thrombopoietin (TPO) on immature hematopoietic progenitor cells were evaluated following total body irradiation.