Akademik Veri Yönetim Sistemi
Hacettepe University Journal of the Faculty of Pharmacy, cilt.39, sa.1, ss.44-57, 2019 (Scopus)
© 2019, Hacettepe University, Faculty of Pharmacy. All rights reserved.Today, a wide range pathological conditions can be caused by exposure to endocrine disrupting chemicals (EDCs) in the general population, particularly in children. The reproductive system is the main target for EDCs whereas several systems and organs can be affected from EDC exposure. Cancer is a pathological condition that affects all of the age groups and socioeconomic classes in both developed and developing countries. Particularly in the last twenty years, cancer incidence is rising throughout the globe. In 2015, nearly 8.8 million people died because of cancer and it is indicated that this corresponds to 1 in 6 of all deaths in the same year. The rise of cancer incidence in particularly industrialized countries is associated with exposure the EDC one by one or in mixtures. However, there is no reliable information in literature about EDCs and how much they can increase different cancer outcomes in humans. In this review, the association of EDCs with cancer is investigated by a comprehensive literature evaluation. Several studies in literature indicated that EDCs may have an impact on the outcome of different cancer types, including cancers of breast, prostate, testis, pancreas as well as Non-Hodgkin Lymphoma and the other type of hematopoietic cancers. In addition, this review also covers and suggests certain precautions for preventing the toxicity of these chemicals, increasing awareness of the society against these compounds and precluding several pathological conditions, including cancer after exposure to endocrine disrupting chemicals.