Effect of interferon beta-1a on serum matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of matrix metalloproteinase (TIMP-1) in relapsing remitting multiple sclerosis patients - One year follow-up results

KARABUDAK R., KURNE A., GUC D., Sengelen M., CANPINAR H., KANSU E.

JOURNAL OF NEUROLOGY, cilt.251, sa.3, ss.279-283, 2004 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 251 Sayı: 3
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1007/s00415-004-0285-7
  • Dergi Adı: JOURNAL OF NEUROLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.279-283
  • Anahtar Kelimeler: multiple sclerosis, IFN beta 1a, matrix metalloproteinases, tissue inhibitors of MMPs, MMP-9, TIMP-1, BLOOD-BRAIN-BARRIER, GELATINASE-B, BETA-1B, MIGRATION, CSF
  • Hacettepe Üniversitesi Adresli: Evet

Özet

There is emerging evidence that matrix metalloproteinases (MMPs) might be involved in blood brain barrier (BBB) breakdown in multiple sclerosis.

There is emerging evidence that matrix metalloproteinases (MMPs) might be involved in blood brain barrier (BBB) breakdown in multiple sclerosis. A group of natural tissue inhibitors of metalloproteinases (TIMPS) regulates proteolytic activity to prevent tissue damage. TIMP-1 and MMP-9 are known to be secreted as heterodimers and TIMP-1 preferentially functions to inhibit MMP-9 activity. In this present study, the effects of IFNbeta-1a on serum MMP-9 and TIMP-1 were evaluated longitudinally during a one-year period. The MMP-9 levels showed no significant changes while TIMP-1 levels gradually and significantly increased during 3rd and 6th months of therapy compared with pretreatment levels.