Cholesterol removal via cyclodextrin-decoration on cellulose nanocrystal (CNC)-grafted poly(HEMA-GMA) nanocomposite adsorbent
CELLULOSE, vol.28, no.1, pp.471-487, 2021 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 28 Issue: 1
- Publication Date: 2021
- Doi Number: 10.1007/s10570-020-03534-7
- Journal Name: CELLULOSE
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, Compendex
- Page Numbers: pp.471-487
- Keywords: Cellulose nanomaterial, Cyclodextrin, Cholesterol, Low density lipoprotein, Removal, WASTE-WATER, ADSORPTION, MONOLITHS, NANOSPHERES, COMPOSITES, MORPHOLOGY, SEPARATION, REDUCTION, EXTRUSION, ION
- Hacettepe University Affiliated: Yes
Abstract
Glycidyl methacrylate (GMA) was grafted to cellulose nanocrystals (CNCs) using hydroquinone resulting in a crosslinkable nanoparticle. 2-Hydroxyethyl methacrylate (HEMA) was used to polymerize this nanoparticle to obtain a polymeric structure with a bridging CNC structure to which cyclodextrin (CD) was attached in order to better capture hydrophobic biomolecules. X-Ray Microscopy and nuclear magnetic resonance methods provided the main characterization data proving the successful modification process. This CD-modified nanocomposite adsorbent was used for the removal of cholesterol and low-density lipoprotein for the first time. Adsorption performance in a continuous system was similar to 99% for both cholesterol and low-density lipoprotein with agreement between experimental data and mathematical models performed. Overall, results indicate that cyclodextrin modified poly(HEMA-GMA-g-CNC) is a promising material for use as an adsorbent for biological and biomedical applications.