Neutrophil Formylpeptide Receptor Single Nucleotide Polymorphism 348T > C in Aggressive Periodontitis

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Maney P., Emecen P., Mills J. S., Walters J. D.

JOURNAL OF PERIODONTOLOGY, vol.80, no.3, pp.492-498, 2009 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 80 Issue: 3
  • Publication Date: 2009
  • Doi Number: 10.1902/jop.2009.080225
  • Journal Name: JOURNAL OF PERIODONTOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.492-498
  • Hacettepe University Affiliated: No

Abstract

Background: Neutrophil formylpeptide receptors (FPRs) play an important role in bacterial recognition and chemotaxis. Defective FPR1 expression and impaired polymorphonuclear leukocyte chemotaxis toward bacterial formylpeptides are associated with aggressive periodontitis (AgP). The objective of this study was to determine whether single nucleotide polymorphisms (SNPs) in FPR1 are associated with AgP.