HDAC Inhibition Overcomes Acute Resistance to MEK Inhibition in BRAF-Mutant Colorectal Cancer by Downregulation of c-FLIPL

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Carson R., ÇELTİKÇİ B. , Fenning C., Javadi A., Crawford N., Perez-Carbonell L., ...Daha Fazla

CLINICAL CANCER RESEARCH, cilt.21, sa.14, ss.3230-3240, 2015 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 21 Konu: 14
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1158/1078-0432.ccr-14-2701
  • Sayfa Sayıları: ss.3230-3240


Purpose: Activating mutations in the BRAF oncogene are found in 8% to 15% of colorectal cancer patients and have been associated with poor survival. In contrast with BRAF-mutant (MT) melanoma, inhibition of the MAPK pathway is ineffective in the majority of BRAFMT colorectal cancer patients. Therefore, identification of novel therapies for BRAFMT colorectal cancer is urgently needed.