Plasma and platelet serotonin levels in familial Mediterranean fever

Onat A. M., Oezcakar L., Oeztuerk M. A., Ucar G., Uereten K., Dagli N., ...More

CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, vol.25, no.4, 2007 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 25 Issue: 4
  • Publication Date: 2007
  • Journal Name: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: FMF, serotonin, inflammation, SSRI, ADJUVANT-INDUCED ARTHRITIS, NECROSIS-FACTOR-ALPHA, SELECTIVE SEROTONIN, REUPTAKE INHIBITORS, DISEASE, PAIN
  • Hacettepe University Affiliated: Yes

Abstract

Objective. Familial Mediterranean fever (FMF) is the most common auto-inflammatory syndrome with exaggerated acute phase and inflammatory response. After revealing the MEFV gene mutation with the finally disturbed end product pyrin, some of the mechanisms were explained. However it is still unknown what triggers or ends these periodical attacks. Moreover, the treatment of up to 30% of the patients, that are resistant to colchicine is still a problem. In this study we investigated the role of serotonin in colchicine-resistant FMF patients.