Plasma and platelet serotonin levels in familial Mediterranean fever

Onat A. M., Oezcakar L., Oeztuerk M. A., Ucar G., Uereten K., Dagli N., ...Daha Fazla

CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, cilt.25, sa.4, 2007 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 25 Sayı: 4
  • Basım Tarihi: 2007
  • Dergi Adı: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: FMF, serotonin, inflammation, SSRI, ADJUVANT-INDUCED ARTHRITIS, NECROSIS-FACTOR-ALPHA, SELECTIVE SEROTONIN, REUPTAKE INHIBITORS, DISEASE, PAIN
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Objective. Familial Mediterranean fever (FMF) is the most common auto-inflammatory syndrome with exaggerated acute phase and inflammatory response. After revealing the MEFV gene mutation with the finally disturbed end product pyrin, some of the mechanisms were explained. However it is still unknown what triggers or ends these periodical attacks. Moreover, the treatment of up to 30% of the patients, that are resistant to colchicine is still a problem. In this study we investigated the role of serotonin in colchicine-resistant FMF patients.