Effects of curcumin-loaded PLGA nanoparticles on the RG2 rat glioma model

Orunoğlu, Merdan; Kaffashi, abbas; PEHLİVAN, SİBEL; ŞAHİN, SELMA; SÖYLEMEZOĞLU, AYŞE; KARLI OĞUZ, HATİCE; MUT AŞKUN, MELİKE

doi:10.1016/j.msec.2017.03.292

Effects of curcumin-loaded PLGA nanoparticles on the RG2 rat glioma model

Orunoğlu M., Kaffashi a., PEHLİVAN S., ŞAHİN S., SÖYLEMEZOĞLU A. F., KARLI OĞUZ H. K., ...Daha Fazla

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, cilt.78, ss.32-38, 2017 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 78
Basım Tarihi: 2017
Doi Numarası: 10.1016/j.msec.2017.03.292
Dergi Adı: MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.32-38
Hacettepe Üniversitesi Adresli: Evet

Özet

Background: Curcumin, the active ingredient of turmeric, has a remarkable antitumor activity against various cancers, including glioblastoma. However, it has poor absorption and low bioavailability; thus, to cross the blood brain barrier and reach tumor tissue, it needs to be transferred to tumor site by special drug delivery systems, such as nanoparticles.