Effects of curcumin-loaded PLGA nanoparticles on the RG2 rat glioma model

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Atıf İçin Kopyala

Orunoğlu M., Kaffashi a., PEHLİVAN S., ŞAHİN S., SÖYLEMEZOĞLU A. F., KARLI OĞUZ H. K., ...Daha Fazla

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, cilt.78, ss.32-38, 2017 (SCI-Expanded)

• Yayın Türü: Makale / Tam Makale
• Cilt numarası: 78
• Basım Tarihi: 2017
• Doi Numarası: 10.1016/j.msec.2017.03.292
• Dergi Adı: MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
• Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Sayfa Sayıları: ss.32-38
• Hacettepe Üniversitesi Adresli: Evet

Özet

Background: Curcumin, the active ingredient of turmeric, has a remarkable antitumor activity against various cancers, including glioblastoma. However, it has poor absorption and low bioavailability; thus, to cross the blood brain barrier and reach tumor tissue, it needs to be transferred to tumor site by special drug delivery systems, such as nanoparticles.