Effects of curcumin-loaded PLGA nanoparticles on the RG2 rat glioma model

Orunoğlu M., Kaffashi a., PEHLİVAN S., ŞAHİN S., SÖYLEMEZOĞLU A. F. , KARLI OĞUZ H. K. , ...More

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, vol.78, pp.32-38, 2017 (SCI-Expanded) identifier identifier identifier


Background: Curcumin, the active ingredient of turmeric, has a remarkable antitumor activity against various cancers, including glioblastoma. However, it has poor absorption and low bioavailability; thus, to cross the blood brain barrier and reach tumor tissue, it needs to be transferred to tumor site by special drug delivery systems, such as nanoparticles.