Effects of curcumin-loaded PLGA nanoparticles on the RG2 rat glioma model

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Orunoğlu M., Kaffashi a., PEHLİVAN S., ŞAHİN S., SÖYLEMEZOĞLU A. F., KARLI OĞUZ H. K., ...More

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, vol.78, pp.32-38, 2017 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 78
• Publication Date: 2017
• Doi Number: 10.1016/j.msec.2017.03.292
• Journal Name: MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.32-38
• Hacettepe University Affiliated: Yes

Abstract

Background: Curcumin, the active ingredient of turmeric, has a remarkable antitumor activity against various cancers, including glioblastoma. However, it has poor absorption and low bioavailability; thus, to cross the blood brain barrier and reach tumor tissue, it needs to be transferred to tumor site by special drug delivery systems, such as nanoparticles.