Prognostic significance of whole blood viscosity estimated by de Simone's formula in ST-elevation myocardial infarction

Cetin E. H. O., Cetin M. S., CANPOLAT U., Aydin S., Aras D., Topaloglu S., ...More

BIOMARKERS IN MEDICINE, vol.10, no.5, pp.495-511, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 10 Issue: 5
  • Publication Date: 2016
  • Doi Number: 10.2217/bmm.16.10
  • Journal Name: BIOMARKERS IN MEDICINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.495-511
  • Keywords: MACE, shear rate, ST-elevation myocardial infarction, whole blood viscosity, CARDIOVASCULAR RISK, SHEAR-STRESS, HEMORHEOLOGICAL FACTORS, UNIVERSAL DEFINITION, ASSOCIATION, REPERFUSION, PARAMETERS, EVENTS
  • Hacettepe University Affiliated: Yes

Abstract

Background: We assessed the predictive value of estimated whole blood viscosity (WBV) in-hospital and long-term cardiovascular outcomes in patients with ST-elevation myocardial infarction (STEMI). Materials & methods: One thousand eight hundred and thirty-five STEMI patients were followed up for median 34.6 months. WBV was calculated consistent with the de Simone's formula. Results: In-hospital and long-term major adverse cardiovascular events (MACE) demonstrated an incremental trend in ascending order of WBV tertiles at low and high shear rate. Kaplan-Meier analysis showed a higher occurrence of long-term MACE in third WBV tertiles compared with other tertiles. Conclusion: WBV seems to be a feasible prognostic indicator of short-and long-term cardiovascular adverse events in patients with STEMI. As an easily available parameter, WBV may be utilized in identifying high-risk patients for subsequent MACE.