Boric acid: a simple molecule of physiologic, therapeutic and prebiotic significance

Zumreoglu-Karan B. , Kose D. A.

PURE AND APPLIED CHEMISTRY, cilt.87, ss.155-162, 2015 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 87 Konu: 2
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1515/pac-2014-0909
  • Sayfa Sayıları: ss.155-162


Boric acid, H3BO3, is a weak acid and at physiological pH is in the form of an uncharged small molecule. Behaving as a Lewis acid, it forms complexes with amino-and hydroxy acids, carbohydrates, nucleotides and vitamins through electron donor-acceptor interactions. These interactions are believed to be beneficial for human health. Synthetic bis-chelate complexes of boric acid with organic biomolecules are therefore considered for nutritional and/or pharmaceutical applications. The use of boric acid for BNCT has gained attention due to the short biological half-life, solubility, plasma circulation and the non-selective soft tissue accumulation properties of this simple molecule. Complexation of boric acid with sugars is of particular importance in understanding the role of boron as a carrier for nucleotides and carbohydrates. A potential and catalytic role of boric acid in peptide and nucleic acid synthesis and in the stabilization of sugar molecules by acting as a complexing agent have been demonstrated. Its possible role as a phosphorylation chaperone in a prebiotic world has been recently suggested. This contribution reviews the highlights in the physiologic, therapeutic and prebiotic significance of boric acid in the last decade.