Evaluation of Th17-related cytokines and receptors in multiple sclerosis patients under interferon beta-1 therapy


ESENDAĞLI G. , Kurne A. T. , Sayat G., Kilic A. K. , Guc D. , KARABUDAK R.

JOURNAL OF NEUROIMMUNOLOGY, cilt.255, ss.81-84, 2013 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 255
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1016/j.jneuroim.2012.10.009
  • Dergi Adı: JOURNAL OF NEUROIMMUNOLOGY
  • Sayfa Sayıları: ss.81-84

Özet

Th17-related cytokines (IL-17, IL-23, and IL-26) and receptors (IL-17R and IL-23R) were evaluated in MS patients under immunomodulatory IFN-beta 1 therapy during a 2 year follow-up. Before the initiation of treatment, no significant difference was found in cytokine or receptor expression between controls and MS patients. Of the three cytokines evaluated, IL-26 was the highest in the patients' sera. The amount of IL-17 and CD13(+)IL-17R(+) cells was steadily decreased whereas IL-23 and IL-26 levels were gradually increased with IFN-beta 1 therapy. The patients in progressive phase had very high levels of IL-17. Th17-associated parameters should be considered in the immunomodulatory IFN-beta 1 therapy of MS. (C) 2012 Elsevier B.V. All rights reserved.