Protective effect of Amifostine against cisplatin-induced motor neuropathy in rat

YALCIN S. F., NURLU G., ORHAN B., ZEYBEK D., Muftuoglu S. F., SARER B., ...More

MEDICAL ONCOLOGY, vol.20, no.2, pp.175-180, 2003 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 20 Issue: 2
  • Publication Date: 2003
  • Doi Number: 10.1385/mo:20:2:175
  • Journal Name: MEDICAL ONCOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.175-180
  • Hacettepe University Affiliated: Yes


Cisplatin (CDDP) is a potent anticancer drug. Neurotoxicity is one of the most important dose-limiting toxicity of CDDP. We investigated the role of amifostine in the protection against CDDP-induced neurotoxicity especially on the motor nerves. All experiments were conducted on female Wistar albino rats. Animals were randomly assigned to two groups, each including six rats. Group A received CDDP plus amifostine and Group B received CDDP only. Electroneurography (ENG) was carried out in the beginning and at the end of 7 wk; then, the rats were sacrificed and the sciatic nerve was removed for histopathological examination.