Protective effect of Amifostine against cisplatin-induced motor neuropathy in rat
MEDICAL ONCOLOGY, vol.20, no.2, pp.175-180, 2003 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 20 Issue: 2
- Publication Date: 2003
- Doi Number: 10.1385/mo:20:2:175
- Journal Name: MEDICAL ONCOLOGY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.175-180
- Hacettepe University Affiliated: Yes
Abstract
Cisplatin (CDDP) is a potent anticancer drug. Neurotoxicity is one of the most important dose-limiting toxicity of CDDP. We investigated the role of amifostine in the protection against CDDP-induced neurotoxicity especially on the motor nerves. All experiments were conducted on female Wistar albino rats. Animals were randomly assigned to two groups, each including six rats. Group A received CDDP plus amifostine and Group B received CDDP only. Electroneurography (ENG) was carried out in the beginning and at the end of 7 wk; then, the rats were sacrificed and the sciatic nerve was removed for histopathological examination.