Design, Synthesis and Investigation of New Diphenyl Substituted Pyridazinone Derivatives as Both Cholinesterase and A beta-Aggregation Inhibitors

KILIÇ B., Erdogan M., Gulcan H. O., Aksakarl F., Oruklu N., Bagriacik E. U., ...More

MEDICINAL CHEMISTRY, vol.15, no.1, pp.59-76, 2019 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 15 Issue: 1
  • Publication Date: 2019
  • Doi Number: 10.2174/1573406414666180524073241
  • Journal Name: MEDICINAL CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.59-76
  • Hacettepe University Affiliated: Yes

Abstract

Background: With respect to the increase in the average life expectancy, Alzheimer Disease (AD), the most common form of age-related dementia, has become a major threat to the population over the age of 65 during the past several decades. The majority of AD treatments are focused on cholinergic and amyloid hypotheses.