Assessment of LXR alpha agonist activity and selective antiproliferative efficacy: a study on different parts of Digitalis species


KUTLUAY V. M. , Inoue M., SARAÇOĞLU İ.

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, vol.44, no.6, pp.745-751, 2019 (Peer-Reviewed Journal) identifier identifier

  • Publication Type: Article / Article
  • Volume: 44 Issue: 6
  • Publication Date: 2019
  • Doi Number: 10.1515/tjb-2018-0280
  • Journal Name: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
  • Journal Indexes: Science Citation Index Expanded, Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.745-751

Abstract

Objective: Aerial parts and roots of three Digitalis species (Digitalis davisiana Heywood, Digitalis viridiflora Lindley and Digitalis grandiflora Miller; Plantaginaceae) were investigated from the viewpoint of cytotoxicity to identify the biologically active parts. Playing a role in cell proliferation and tumor growth, LXR alpha agonist activity also has become of interest to researchers investigating its relationship with the cytotoxicity.