Assessment of LXR alpha agonist activity and selective antiproliferative efficacy: a study on different parts of Digitalis species


KUTLUAY V. M. , Inoue M., SARAÇOĞLU İ.

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, cilt.44, ss.745-751, 2019 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 44 Konu: 6
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1515/tjb-2018-0280
  • Dergi Adı: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
  • Sayfa Sayıları: ss.745-751

Özet

Objective: Aerial parts and roots of three Digitalis species (Digitalis davisiana Heywood, Digitalis viridiflora Lindley and Digitalis grandiflora Miller; Plantaginaceae) were investigated from the viewpoint of cytotoxicity to identify the biologically active parts. Playing a role in cell proliferation and tumor growth, LXR alpha agonist activity also has become of interest to researchers investigating its relationship with the cytotoxicity.