THE RELATIONSHIP BETWEEN THE EXPRESSION LEVELS OF TISSUE INHIBITOR OF METALLOPROTEINASES-3 (TIMP3) AND SEVERITY OF ATHEROSCLEROSIS


Çelebi G., Guclu Geyik F., Yilmazbayhan D., Ozsoy D., YILDIZ C. E. , YILDIZ M., ...More

JOURNAL OF ISTANBUL FACULTY OF MEDICINE-ISTANBUL TIP FAKULTESI DERGISI, vol.84, no.4, pp.472-481, 2021 (Peer-Reviewed Journal) identifier identifier

  • Publication Type: Article / Article
  • Volume: 84 Issue: 4
  • Publication Date: 2021
  • Doi Number: 10.26650/iuitfd.2021.896230
  • Journal Name: JOURNAL OF ISTANBUL FACULTY OF MEDICINE-ISTANBUL TIP FAKULTESI DERGISI
  • Journal Indexes: Emerging Sources Citation Index, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.472-481
  • Keywords: Atherosclerosis, TIMP3, gene expression level, coronary artery, adipocyte, leukocyte, EPICARDIAL ADIPOSE-TISSUE, INSULIN-RESISTANCE, INFLAMMATION, DISEASE, OVEREXPRESSION, PROGRESSION, FAT

Abstract

Objective: Tissue Inhibitor of Metalloproteinase-3 human (TIMP3) is one of tissue inhibitors of metalloproteinases (TIMPs), which binds to the components of the extracellular matrix, and has cru-cial roles in atherosclerogenesis and adipose tissue differentiation. In this study, it was aimed to determine the effects of TIMP3 gene expression levels on severity of atherosclerosis in different tissues.