THE RELATIONSHIP BETWEEN THE EXPRESSION LEVELS OF TISSUE INHIBITOR OF METALLOPROTEINASES-3 (TIMP3) AND SEVERITY OF ATHEROSCLEROSIS

Çelebi, Gizem; Guclu Geyik, Filiz; Yilmazbayhan, Dilek; Ozsoy, Deniz; YILDIZ, Cenk; YILDIZ, Mustafa; Oksen, Dogac; CAVLAK, MEHMET; Komurcu Bayrak, Evrim

doi:10.26650/iuitfd.2021.896230

THE RELATIONSHIP BETWEEN THE EXPRESSION LEVELS OF TISSUE INHIBITOR OF METALLOPROTEINASES-3 (TIMP3) AND SEVERITY OF ATHEROSCLEROSIS

Çelebi G., Guclu Geyik F., Yilmazbayhan D., Ozsoy D., YILDIZ C. E., YILDIZ M., ...Daha Fazla

JOURNAL OF ISTANBUL FACULTY OF MEDICINE-ISTANBUL TIP FAKULTESI DERGISI, cilt.84, sa.4, ss.472-481, 2021 (ESCI)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 84 Sayı: 4
Basım Tarihi: 2021
Doi Numarası: 10.26650/iuitfd.2021.896230
Dergi Adı: JOURNAL OF ISTANBUL FACULTY OF MEDICINE-ISTANBUL TIP FAKULTESI DERGISI
Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
Sayfa Sayıları: ss.472-481
Anahtar Kelimeler: Atherosclerosis, TIMP3, gene expression level, coronary artery, adipocyte, leukocyte, EPICARDIAL ADIPOSE-TISSUE, INSULIN-RESISTANCE, INFLAMMATION, DISEASE, OVEREXPRESSION, PROGRESSION, FAT
Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
Hacettepe Üniversitesi Adresli: Evet

Özet

Objective: Tissue Inhibitor of Metalloproteinase-3 human (TIMP3) is one of tissue inhibitors of metalloproteinases (TIMPs), which binds to the components of the extracellular matrix, and has cru-cial roles in atherosclerogenesis and adipose tissue differentiation. In this study, it was aimed to determine the effects of TIMP3 gene expression levels on severity of atherosclerosis in different tissues.