Does serotonin relax the rat anococcygeus muscle via 5-HT7 receptors?


Emre S., Erdem S., Tuncer M.

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, cilt.362, ss.96-100, 2000 (SCI İndekslerine Giren Dergi) identifier

  • Cilt numarası: 362 Konu: 2
  • Basım Tarihi: 2000
  • Doi Numarası: 10.1007/s002100000245
  • Dergi Adı: NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
  • Sayfa Sayıları: ss.96-100

Özet

The mechanisms of serotonin (5-HT)-induced contraction and relaxation were studied in the rat anococcygeus muscle. In the presence of prazosin (1 nM) and ketanserin (10 nM), concentration/response curves to 5-HT were shifted to the right and the maximum effects were not affected (pK(B), values 9.09+/-0.29 and 8.66+/-0.06 for prazosin and ketanserin, respectively). On contrary, guanethidine (10 mu M) antagonised the 5-MT-induced contractions non-competitively. In the presence of guanethidine, prazosin or ketanserin further inhibited the responses to 5-HT at lower concentrations. The serotonergic receptor agonists 5-carboxamidotrypamine, metoclopramide and sumatriptan did not produce any effect in tissues under baseline conditions.