Akademik Veri Yönetim Sistemi
Hacettepe University Journal of the Faculty of Pharmacy, cilt.35, sa.1, ss.1-19, 2015 (Scopus)
© 2015, Hacettepe University, Faculty of Pharmacy. All rights reserved.Today, exposure to endocrine disrupting chemicals is abundantly high, particularly in developed countries. The observations indicate a high correlation between the increasing prevalence of thyroid diseases and exposure to high concentrations of polychlorinated biphenyls, phthalates and bisphenol A in the last 50 years. Exposure to those chemicals were found to alter thyroid structure, thyroid hormones and thyroid-related genes in in vivo and in vitro descriptive and mechanistic studies. Though human data are limited, the results of the conducted studies suggest that these substances act like thyroid analogues or bind to thyroid receptors and disrupt thyroid hormone signaling pathways. The aim of this review is to evaluate the possible effects of endocrine disrupting chemicals on thyroid and to discuss the results of animal and human studies.