Reactivation of cAMP Pathway by PDE4D Inhibition Represents a Novel Druggable Axis for Overcoming Tamoxifen Resistance in ER-positive Breast Cancer

Mishra, Rasmi; Belder, Nevin; Ansari, Suhail; Kayhan, Merve; Bal, Hilal; Raza, Umar; Ersan, Pelin; Tokat, Unal; Eyupoglu, Erol; Saatci, Ozge; Jandaghi, Pouria; Wiemann, Stefan; ÜNER, AYŞEGÜL; ÇEKİÇ, ÇAĞLAR; Riazalhosseini, Yasser; ŞAHİN, ÖZGÜR

doi:10.1158/1078-0432.ccr-17-2776

Reactivation of cAMP Pathway by PDE4D Inhibition Represents a Novel Druggable Axis for Overcoming Tamoxifen Resistance in ER-positive Breast Cancer

Mishra R. R., Belder N., Ansari S. A., Kayhan M., Bal H., Raza U., ...Daha Fazla

CLINICAL CANCER RESEARCH, cilt.24, sa.8, ss.1987-2001, 2018 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 24 Sayı: 8
Basım Tarihi: 2018
Doi Numarası: 10.1158/1078-0432.ccr-17-2776
Dergi Adı: CLINICAL CANCER RESEARCH
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.1987-2001
Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
Hacettepe Üniversitesi Adresli: Evet

Özet

Purpose: Tamoxifen remains an important hormonal therapy for ER-positive breast cancer; however, development of resistance is a major obstacle in clinics. Here, we aimed to identify novel mechanisms of tamoxifen resistance and provide actionable drug targets overcoming resistance.