Calc-alkaline rocks of the Hasan Dagi volcano (Central Anatolia, Turkey) are products of arc volcanism triggered by continental collision. Volcanic rocks of the Hasan Dagi range in composition from basalt to rhyolite but are dominated by andesite and dacite. Considering only the mass transfer part of the process leads to an incomplete picture of magma chamber processes. The exclusion of simultaneous calculations of heat and mass transfer between mixing magmas, however, has prevented petrologists from gaining new insights into the magma mixing process. Thus, we report our experimental results in conjunction with modeling with MELTS to test the ideas concerning the petrogenesis of Hasan Dagi volcanic rocks and quantitatively model the relevant petrogenetic processes. Our results demonstrate that the chemical diversity of Hasan Dagi volcano is inconsistent with the closed-system crystallization and differentiation. Thus, (1) our experimental modeling, (2) the agreement between the liquid line of descent defined by the natural rock data and the MELTS calculations, and (3) the agreement between the mineralogy of the rocks and calculated mineralogy corroborate the conclusion that the isobaric-isenthalpic magma mixing of basalt and rhyolite is the major controlling process in the petrogenesis of the Hasan Dagi magmas.