Investigation of cognitive functions in children with bone tumours and lymphoma in treatment process


Önal G., Davutoğlu C., ŞAHİN S.

Child: Care, Health and Development, vol.50, no.1, 2024 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 50 Issue: 1
  • Publication Date: 2024
  • Doi Number: 10.1111/cch.13139
  • Journal Name: Child: Care, Health and Development
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus, Academic Search Premier, ASSIA, CAB Abstracts, Child Development & Adolescent Studies, CINAHL, Communication & Mass Media Index, EBSCO Education Source, EMBASE, Index Islamicus, MEDLINE, PAIS International, Psycinfo, Public Affairs Index, Veterinary Science Database
  • Keywords: bone tumours, children with cancer, cognitive functions, lymphoma, neurocognition
  • Hacettepe University Affiliated: Yes

Abstract

Background: Neurocognitive sequelae are among the most debilitating effects of cancer observed in children. Yet we know very little about the impact on neurocognitive functioning, especially cancer types that develop outside the central nervous system. This study aimed to assess and compare the cognitive functions (CoF) of children with bone tumours and lymphoma in the treatment process. Methods: The CoF of children with bone tumours (n = 44), lymphoma (n = 42) and their non-cancer peers (n = 55) were assessed with Dynamic Occupational Therapy Assessment for Children. The CoF of children with cancer were compared with their non-cancer peers. Then, children with bone tumours and lymphoma were compared in binary. Results: One-hundred forty-one children aged 6–12 years with a mean age of 9.4 (SD = 1.5) were included in this study. The orientation and visuomotor construction functions of children with bone tumours and orientation, praxis and visuomotor construction functions of children with lymphoma performed worse than their non-cancer peers (pk < 0.001). While orientation, spatial perception, visuomotor construction and thinking operations functions of children with bone tumours and lymphoma were similar (pk > 0.016), praxis functions of children with lymphoma were found to be worse than children with bone tumours (pk < 0.016). Conclusions: Our findings show that children with bone tumours and lymphoma in the process of treatment are at risk for impairment of their CoF. The findings highlight the importance of assessing CoF in children with bone tumours and lymphoma and considering specific differences between groups. It is essential to assess CoF and develop early intervention plans in these children.