Prevention of renal ischemia/reperfusion-induced injury in rats by leflunomide

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Karaman A., Turkmen E., Gursul C., Tas E., Fadillioglu E.

INTERNATIONAL JOURNAL OF UROLOGY, vol.13, no.11, pp.1434-1441, 2006 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 13 Issue: 11
• Publication Date: 2006
• Doi Number: 10.1111/j.1442-2042.2006.01592.x
• Journal Name: INTERNATIONAL JOURNAL OF UROLOGY
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.1434-1441
• Hacettepe University Affiliated: Yes

Abstract

Objective: There is increasing evidence to suggest that toxic oxygen radicals play an essential role in the pathogenesis of ischemia/reperfusion (I/R) injury in the kidney. This study was designed to investigate the effects of leflunomide, an isoxazole derivative and a unique immunomodulatory agent, in I/R-induced renal injury in rats.