Prevention of renal ischemia/reperfusion-induced injury in rats by leflunomide

Karaman A., Turkmen E., Gursul C., Tas E., Fadillioglu E.

INTERNATIONAL JOURNAL OF UROLOGY, vol.13, no.11, pp.1434-1441, 2006 (SCI-Expanded) identifier identifier identifier


Objective: There is increasing evidence to suggest that toxic oxygen radicals play an essential role in the pathogenesis of ischemia/reperfusion (I/R) injury in the kidney. This study was designed to investigate the effects of leflunomide, an isoxazole derivative and a unique immunomodulatory agent, in I/R-induced renal injury in rats.