INTERNATIONAL JOURNAL OF UROLOGY, cilt.13, sa.11, ss.1434-1441, 2006 (SCI-Expanded)
Objective: There is increasing evidence to suggest that toxic oxygen radicals play an essential role in the pathogenesis of ischemia/reperfusion (I/R) injury in the kidney. This study was designed to investigate the effects of leflunomide, an isoxazole derivative and a unique immunomodulatory agent, in I/R-induced renal injury in rats.