Photodegradation studies of 1,4-dihydropyridine compounds by MCR analysis on UV spectral data

Ioele G., GÜNDÜZ M. G., DE LUCA M., ŞİMŞEK R., Safak C., MUZZALUPO R., ...More

FUTURE MEDICINAL CHEMISTRY, vol.8, no.2, pp.107-115, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 8 Issue: 2
  • Publication Date: 2016
  • Doi Number: 10.4155/fmc.15.172
  • Journal Name: FUTURE MEDICINAL CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.107-115
  • Keywords: 1,4-dihydropyridine compounds, chemometric analysis, photodegradation, spectrophotometric analysis, stress test, MULTIVARIATE CURVE RESOLUTION, WAVELET TRANSFORM, ANTIHYPERTENSIVES, LACIDIPINE, PLS
  • Hacettepe University Affiliated: Yes

Abstract

Background: 1,4-Dihydropyridines (DHPs) are well-known light-sensitive compounds. Photostability studies are necessary to ensure safety in therapy. Materials & methods: Photodegradation experiments on 15 condensed DHP derivatives were made according to the International Conference on Harmonization rules. Degradation profiles were monitored by spectrophotometry and the data were processed by multivariate curve resolution analysis. Results: The analysis of the spectral data showed the formation of a single photoproduct from two DHPs, due to the aromatization of the pyridine ring. Traces of a second photoproduct were revealed in 12 DHPs and a third photoproduct was verified only in one case. Conclusion: DHPs showed high stability when fluorine was in the position R-1 of the phenyl ring or simultaneously present in R-1 and R-2 positions. In contrast, the presence of chlorine in R-1 or R-2 strongly increased the degradation.