Effect of melatonin on cerebral edema in rats

GORGULU A., PALAOGLU S., ISMAILOGLU O., TUNCEL M., SURUCU M., Erbil M., ...More

NEUROSURGERY, vol.49, no.6, pp.1434-1441, 2001 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 49 Issue: 6
  • Publication Date: 2001
  • Doi Number: 10.1097/00006123-200112000-00024
  • Journal Name: NEUROSURGERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1434-1441
  • Hacettepe University Affiliated: Yes

Abstract

OBJECTIVE: Melatonin (5-methoxy-N-acetyltrypamine), a chemical naturally produced in the pineal gland, has been suggested to be a free radical scavenger and an antioxidant. In the present study, the effect of melatonin on cold-induced brain edema was evaluated by determination of cerebral water content, blood-brain barrier permeability, and areas of infarct; the effects were also studied histopathologically.