Effect of melatonin on cerebral edema in rats

GORGULU A., PALAOGLU S., ISMAILOGLU O., TUNCEL M., SURUCU M., Erbil M., ...Daha Fazla

NEUROSURGERY, cilt.49, sa.6, ss.1434-1441, 2001 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 49 Sayı: 6
  • Basım Tarihi: 2001
  • Doi Numarası: 10.1097/00006123-200112000-00024
  • Dergi Adı: NEUROSURGERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1434-1441
  • Hacettepe Üniversitesi Adresli: Evet

Özet

OBJECTIVE: Melatonin (5-methoxy-N-acetyltrypamine), a chemical naturally produced in the pineal gland, has been suggested to be a free radical scavenger and an antioxidant. In the present study, the effect of melatonin on cold-induced brain edema was evaluated by determination of cerebral water content, blood-brain barrier permeability, and areas of infarct; the effects were also studied histopathologically.