Effect of melatonin on cerebral edema in rats


GORGULU A. , PALAOGLU S., ISMAILOGLU O., TUNCEL M. , SURUCU M. , Erbil M., ...Daha Fazla

NEUROSURGERY, cilt.49, ss.1434-1441, 2001 (SCI İndekslerine Giren Dergi) identifier identifier identifier

Özet

OBJECTIVE: Melatonin (5-methoxy-N-acetyltrypamine), a chemical naturally produced in the pineal gland, has been suggested to be a free radical scavenger and an antioxidant. In the present study, the effect of melatonin on cold-induced brain edema was evaluated by determination of cerebral water content, blood-brain barrier permeability, and areas of infarct; the effects were also studied histopathologically.