Association between nesfatin-1 hormone levels, anthropometric measurements, and glucose regulation shortly after sleeve gastrectomy: A cross-sectional study

Sivaslıoğlu A., Buluş H., Öztürk D., Aksoy E. K., GÖKTAŞ Z.

International Journal of Diabetes in Developing Countries, 2023 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Publication Date: 2023
  • Doi Number: 10.1007/s13410-023-01297-y
  • Journal Name: International Journal of Diabetes in Developing Countries
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, CINAHL, EMBASE, Food Science & Technology Abstracts, Veterinary Science Database
  • Keywords: Bariatric surgery, Nesfatin-1, Nutrition, Obesity, Type 2 diabetes
  • Hacettepe University Affiliated: Yes


Objective: This cross-sectional study was planned to evaluate the relationship between serum nesfatin-1 levels, glucose regulation and anthropometric measurements of individuals who had undergone sleeve gastrectomy. Methods: A total of 40 participants aged between 19 and 64 years with a body mass index (BMI) greater than 30 kg/m2 who underwent sleeve gastrectomy participated in the study. Before and 1 month after the surgery, serum nesfatin-1, fasting insulin levels, anthropometric measurements and biochemical parameters were assessed. Results: Serum nesfatin-1 levels significantly decreased 4 weeks after the surgery (108.3 ± 58.35 pg/mL versus 74.6 ± 40.12 pg/mL: p = 0.003). Serum insulin levels (µIU/ml) showed a similar decrease (p < 0.001). Change in serum nesfatin-1 levels significantly correlated with change in BMI and body fat mass (p = 0.009, p = 0.007, respectively). Furthermore, serum nesfatin-1 levels significantly correlated with total cholesterol levels (p = 0.037). However, despite the significant decreases in both nesfatin-1 levels and glucose regulation markers, no correlation was found between them. The significant decrease observed in post-operative serum nesfatin-1 levels was found to be correlated with anthropometric measurements. Conclusions: This finding highlights the anorexigenic effects of nesfatin-1, and therefore, nesfatin-1 may be an effective factor in obesity treatment and diabetes.