Cyclosporine A-induced acute hepatotoxicity in guinea pigs is associated with endothelin-mediated decrease in local hepatic blood flow

ERDEM Ş. R., Emre-Aydingoz S., ATİLLA P., ÇAKAR A. N., DALKARA T., Bolay H., ...Daha Fazla

LIFE SCIENCES, cilt.88, ss.753-760, 2011 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 88
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1016/j.lfs.2011.02.015
  • Dergi Adı: LIFE SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.753-760
  • Anahtar Kelimeler: Cyclosporine A, Endothelin, Hepatotoxicity, Guinea pigs, Laser Doppler flowmeter, ISOLATED GALLBLADDER STRIPS, TRANSPLANT RECIPIENTS, EPITHELIAL-CELLS, NITRIC-OXIDE, IN-VITRO, RAT, LIVER, CONTRACTION, CHOLESTASIS, INVOLVEMENT
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Aims: To bring further insight into the mechanism of cyclosporine A (CsA)-induced hepatotoxicity, the acute effect of CsA on local hepatic blood flow (LHBF) and its association with systemic hemodynamics, histopathological and biochemical indicators of liver toxicity were studied in guinea pigs in vivo. The association of endothelin (ET) and/or Cremophor-EL (C-EL, vehicle in parenteral CsA preparation) with CsA effects was also investigated.