The Evaluation of Neutrophil-Lymphocyte Ratio in Alzheimer's Disease

KUYUMCU M. E., YEŞİL Y., ÖZTÜRK Z. A., Kizilarslanoglu C., Etgul S., HALİL M. G., ...Daha Fazla

DEMENTIA AND GERIATRIC COGNITIVE DISORDERS, cilt.34, sa.2, ss.69-74, 2012 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 34 Sayı: 2
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1159/000341583
  • Dergi Adı: DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.69-74
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Background/Aim: There is growing consensus in the literature that inflammation plays a significant role in the pathophysiology of Alzheimer's disease (AD). The blood neutrophil-lymphocyte ratio (NLR) is a new, inexpensive and easily applicable marker of inflammation. The aim of this study was to investigate the association between NLR, as an inflammatory biomarker, and AD. Methods: 241 AD patients and 175 patients with normal cognitive function were evaluated in this study. Results: The mean +/- SD NLR of AD patients was significantly higher than that of patients with normal cognitive function (3.21 +/- 1.35 vs. 2.07 +/- 0.74, p < 0.001, respectively). Receiver operating characteristic curve analysis suggested that the optimum NLR cutoff point for AD was 2.48 with 69.29% sensitivity, 79.43% specificity, 82.30% positive predictive values and 65.30% negative predictive values. Logistic regression analysis showed that elevated NLR (OR: 4.774, 95% CI: 2.821-8.076, p < 0.001) was an independent variable for predicting AD. Conclusion: Elderly people with AD have higher NLR than healthy controls. Elevated NLR levels are usually considered as an inflammatory marker. The results of this study suggested that inflammation plays a role in the pathogenesis of AD. Copyright (C) 2012 S. Karger AG, Basel