Advanced Biosensors for Breast Cancer Diagnosis
Nano Theragnostics in Breast Cancer: Advances, Challenges, and Future Prospects, Springer Nature, ss.555-575, 2026
- Yayın Türü: Kitapta Bölüm / Araştırma Kitabı
- Basım Tarihi: 2026
- Doi Numarası: 10.1007/978-981-95-3682-5_15
- Yayınevi: Springer Nature
- Sayfa Sayıları: ss.555-575
- Anahtar Kelimeler: Biomarker, Biosensor, Breast cancer, Electroimpedance, Fluorescence, HER2, SERS, Voltammetry
- Hacettepe Üniversitesi Adresli: Evet
Özet
Prompt and correct diagnosis of breast cancer is important in minimizing mortality and maximizing treatment success. Routine diagnostic tools like mammography, ultrasound, and biopsy work well but are usually hindered by drawbacks in sensitivity, invasiveness, and availability. This chapter addresses the frontier subject of advanced biosensors, which are intended to be analytical tools that integrate a biological recognition component with a transducer to provide early, noninvasive, and highly sensitive detection of breast cancer biomarkers. Biosensors facilitate rapid point-of-care diagnosis and will be forced to march forward with advances in nanomaterials, microfluidics, and bioelectronics. This chapter covers an extended range of biosensor platforms, including electrochemical, optical, piezoelectric, and thermal sensors, and how nanotechnology advances have enormously improved the sensitivity of biosensors, particularly through the integration of materials such as carbon nanotubes, gold nanoparticles, and graphene. For example, colorimetric biosensors based on gold nanoparticles for the detection of HER2 permit naked-eye visual diagnosis in less than 30 min, perfect for low-resource environments. Anti-CA 15-3 antibody-coated surface plasmon resonance sensors provide real-time label-free detection of breast cancer biomarkers in serum at sub-nanomolar sensitivity. Microfluidic lab-on-a-chip biosensors with the incorporation of magnetic nanoparticles for the isolation of circulating tumor cells have demonstrated good performance in the early diagnosis of breast cancer with minimal sample volume. Electrochemical biosensors using carbon nanotube networks have made portable, smartphone-compatible tests accessible for rapid field-level diagnosis of breast cancer. This chapter offers an in-depth review of the design, functionality, and clinical usefulness of state-of-the-art biosensors, highlighting their revolutionary application for personalized medicine, telemedicine diagnostics, and targeted cancer therapy. Topics including sensor reproducibility, regulatory processes, and integration into digital health platforms are also discussed to inform future developments.