High daily fraction dose external radiotherapy for T1 glottic carcinoma: Treatment results and prognostic factors


GÜLTEKİN M. , Ozyar E., CENGİZ M. , ÖZYİĞİT G. , HAYRAN K. M. , Hosal S., ...Daha Fazla

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, cilt.34, ss.1009-1014, 2012 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 34 Konu: 7
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1002/hed.21860
  • Dergi Adı: HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
  • Sayfa Sayıları: ss.1009-1014

Özet

Background The purpose of this study was to investigate the prognostic factors and treatment results of T1N0M0 glottic laryngeal carcinoma irradiated with 2.3 Gray (Gy) per fraction. Methods A total of 183 patients with glottic carcinoma treated between June 1998 and January 2007 were retrospectively evaluated. Of the 183 patients, 163 patients (89%) had T1a and 20 patients (11%) had T1b disease. All patients received 2.3 Gy per fraction to a median total dose of 64.4 Gy. Results The median follow-up was 63 months. The 5-year overall survival (OS), local control, and cancer-specific survival rates were 89%, 81%, and 90%, respectively. Multivariate analysis showed overall treatment time and age to be significant prognostic factors for local control and OS. We observed no grade IV or grade V acute toxicity. Tracheaesophageal fistula as late toxicity was observed in only 1 patient. Conclusions High daily fraction scheme seems to be a feasible schedule for early glottic carcinomas. (c) 2011 Wiley Periodicals, Inc. Head Neck, 2012