Caffeic acid phenethyl ester as a remedial agent for reproductive functions and oxidative stress-based pathologies of gonads

Akyol S., Akbas A., Butun I., Toktas M., Ozyurt H., ŞAHİN Ş., ...Daha Fazla

JOURNAL OF INTERCULTURAL ETHNOPHARMACOLOGY, cilt.4, sa.2, ss.187-191, 2015 (ESCI) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 4 Sayı: 2
  • Basım Tarihi: 2015
  • Doi Numarası: 10.5455/jice.20150402062823
  • Dergi Adı: JOURNAL OF INTERCULTURAL ETHNOPHARMACOLOGY
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Directory of Open Access Journals
  • Sayfa Sayıları: ss.187-191
  • Hacettepe Üniversitesi Adresli: Evet

Özet

In recent years, the studies on the roles of caffeic acid phenethyl ester (CAPE) in several disease models and cell cultures are tremendously growing. It is such a great molecule that was used by ancient times to ameliorate some diseases and nowadays, it is used by modern medicine to test the effectiveness. In this mini-review article, the protection capability of CAPE, as a liposoluble antioxidant and a potent nuclear factor kappa B inhibitor, on oxidative and non-oxidative ovary, and testis damages has been summarized. In view of our laboratory findings/experience and those reported in the hitherto literature, we suggest that CAPE possesses protective effects for pathologies of the reproductive organs induced by untoward effects of harmful molecules such as free oxygen radicals, pesticides, methotrexate, and MK-801 (dizocilpine).