Immunization in multiple sclerosis and other childhood immune-mediated disorders of the central nervous system: A review of the literature

SOLMAZ İ., Anlar B.

EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY, vol.33, pp.125-134, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 33
  • Publication Date: 2021
  • Doi Number: 10.1016/j.ejpn.2021.06.002
  • Journal Name: EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
  • Page Numbers: pp.125-134
  • Keywords: Multiple sclerosis, Pediatric, Vaccines, Immunization, Disease modifying drug, ACUTE DISSEMINATED ENCEPHALOMYELITIS, HEPATITIS-B VACCINATION, BACILLE-CALMETTE-GUERIN, VARICELLA-ZOSTER-VIRUS, DEMYELINATING DISEASES, HPV VACCINATION, RISK-FACTORS, INTERIM RECOMMENDATION, INFLUENZA VACCINATION, ADVISORY-COMMITTEE
  • Hacettepe University Affiliated: Yes

Abstract

Childhood is a period where most vaccines are administered in order to build-up immunological memory, and immunization against vaccine-preventable diseases is an essential part of child care and health. The administration of vaccines to children with inflammatory diseases is a frequent point of concern for parents and physicians. Published information on the relation between vaccines and auto inflammatory diseases of the central nervous system (CNS) consists of case and cohort studies and reviews, in great majority on adult patients. Vaccines do not have any established causative or triggering effects on these diseases. Another issue is the immunization schedule of patients with autoinflammatory CNS diseases, specifically the interactions between the disorder, the clinical status, the treatment and the vaccine. In this review, we summarize the existing information between autoinflammatory disorders of the CNS and vaccines in childhood and underline the points to be considered under various treatment regimens. (c) 2021 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.