Antimicrobial and antimalarial activities of secondary metabolites from some Turkish Verbascum species


Tatli İ. İ. , AKDEMİR Z. Ş.

Fabad Journal of Pharmaceutical Sciences, vol.30, no.2, pp.84-92, 2005 (Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 30 Issue: 2
  • Publication Date: 2005
  • Journal Name: Fabad Journal of Pharmaceutical Sciences
  • Journal Indexes: Scopus
  • Page Numbers: pp.84-92
  • Hacettepe University Affiliated: Yes

Abstract

Antimicrobial and antimalarial activities of 22 secondary metabolites isolated from the methanolic extracts of Verbascum cilicicum Boiss., Verbascum lasianthum Boiss. ex Bentham and Verbascum pterocalycinum var. mutense Hub.-Mor. (Scrophulariaceae) were investigated. Growth inhibition, using microdilution method, was determined against Candida albicans ATCC 90028, Cryptococcus neoformans ATCC 90113, Staphylococcus aureus ATCC 29213, methicillin-resistant S. aureus ATCC 43300, Pseudomonas aeruginosa ATCC 27853, Aspergillus fumigatus ATCC 90906 and Mycobacterium intracellulare ATCC 23068. Amphotericin B, ciprofloxacin and rifampin were used as controls. It was found that ilwensisaponin A and C showed antimicrobial activity against Aspergillus fumigatus ATCC 90906, but no activity was seen against Gram (+) and Gram (-) bacteria and the yeasts used in this study. None of the other compounds had antimicrobial activities. The antimalarial activities of the compounds were also tested to Plasmodium falciparum clone [Sierra Leone D6 and W2 (chloroquine-sensitive)]. The antimalarial agents chloroquine and artemisinin were used as controls. None of the compounds showed antimalarial activities.