Increased Proteolysis, Myosin Depletion, and Atrophic AKT-FOXO Signaling in Human Diaphragm Disuse


Levine S., Biswas C., Dierov J., Barsotti R., Shrager J. B., Taitan Nguyen T. N., ...More

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, vol.183, no.4, pp.483-490, 2011 (SCI-Expanded) identifier identifier

Abstract

Rationale: Patients on mechanical ventilation who exhibit diaphragm inactivity for a prolonged time (case subjects) develop decreases in diaphragm force-generating capacity accompanied by diaphragm myofiber atrophy.