Increased Proteolysis, Myosin Depletion, and Atrophic AKT-FOXO Signaling in Human Diaphragm Disuse

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Levine S., Biswas C., Dierov J., Barsotti R., Shrager J. B., Taitan Nguyen T. N., ...More

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, vol.183, no.4, pp.483-490, 2011 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 183 Issue: 4
• Publication Date: 2011
• Doi Number: 10.1164/200910-1487oc
• Journal Name: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.483-490
• Hacettepe University Affiliated: No

Abstract

Rationale: Patients on mechanical ventilation who exhibit diaphragm inactivity for a prolonged time (case subjects) develop decreases in diaphragm force-generating capacity accompanied by diaphragm myofiber atrophy.