Increased Proteolysis, Myosin Depletion, and Atrophic AKT-FOXO Signaling in Human Diaphragm Disuse

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Atıf İçin Kopyala

Levine S., Biswas C., Dierov J., Barsotti R., Shrager J. B., Taitan Nguyen T. N., ...Daha Fazla

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, cilt.183, sa.4, ss.483-490, 2011 (SCI-Expanded)

• Yayın Türü: Makale / Tam Makale
• Cilt numarası: 183 Sayı: 4
• Basım Tarihi: 2011
• Doi Numarası: 10.1164/200910-1487oc
• Dergi Adı: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
• Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Sayfa Sayıları: ss.483-490
• Hacettepe Üniversitesi Adresli: Hayır

Özet

Rationale: Patients on mechanical ventilation who exhibit diaphragm inactivity for a prolonged time (case subjects) develop decreases in diaphragm force-generating capacity accompanied by diaphragm myofiber atrophy.