Increased Proteolysis, Myosin Depletion, and Atrophic AKT-FOXO Signaling in Human Diaphragm Disuse

Levine, Sanford; Biswas, Chhanda; Dierov, Jamil; Barsotti, Robert; Shrager, Joseph; Taitan Nguyen, Taitan; Sonnad, Seema; Kucharchzuk, John; Kaiser, Larry; Singhal, Sunil; Budak, MURAT

doi:10.1164/200910-1487oc

Increased Proteolysis, Myosin Depletion, and Atrophic AKT-FOXO Signaling in Human Diaphragm Disuse

Levine S., Biswas C., Dierov J., Barsotti R., Shrager J. B. , Taitan Nguyen T. N. , ...Daha Fazla

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, cilt.183, sa.4, ss.483-490, 2011 (SCI İndekslerine Giren Dergi)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 183 Konu: 4
Basım Tarihi: 2011
Doi Numarası: 10.1164/200910-1487oc
Dergi Adı: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
Sayfa Sayıları: ss.483-490

Özet

Rationale: Patients on mechanical ventilation who exhibit diaphragm inactivity for a prolonged time (case subjects) develop decreases in diaphragm force-generating capacity accompanied by diaphragm myofiber atrophy.