Increased Proteolysis, Myosin Depletion, and Atrophic AKT-FOXO Signaling in Human Diaphragm Disuse

Levine, Sanford; Biswas, Chhanda; Dierov, Jamil; Barsotti, Robert; Shrager, Joseph; Taitan Nguyen, Taitan; Sonnad, Seema; Kucharchzuk, John; Kaiser, Larry; Singhal, Sunil; Budak, MURAT

doi:10.1164/200910-1487oc

Increased Proteolysis, Myosin Depletion, and Atrophic AKT-FOXO Signaling in Human Diaphragm Disuse

Levine S., Biswas C., Dierov J., Barsotti R., Shrager J. B., Taitan Nguyen T. N., ...Daha Fazla

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, cilt.183, sa.4, ss.483-490, 2011 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 183 Sayı: 4
Basım Tarihi: 2011
Doi Numarası: 10.1164/200910-1487oc
Dergi Adı: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.483-490
Hacettepe Üniversitesi Adresli: Hayır

Özet

Rationale: Patients on mechanical ventilation who exhibit diaphragm inactivity for a prolonged time (case subjects) develop decreases in diaphragm force-generating capacity accompanied by diaphragm myofiber atrophy.