Increased Proteolysis, Myosin Depletion, and Atrophic AKT-FOXO Signaling in Human Diaphragm Disuse

Levine S., Biswas C., Dierov J., Barsotti R., Shrager J. B., Taitan Nguyen T. N., ...More

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, vol.183, no.4, pp.483-490, 2011 (SCI-Expanded) identifier identifier


Rationale: Patients on mechanical ventilation who exhibit diaphragm inactivity for a prolonged time (case subjects) develop decreases in diaphragm force-generating capacity accompanied by diaphragm myofiber atrophy.