Increased Proteolysis, Myosin Depletion, and Atrophic AKT-FOXO Signaling in Human Diaphragm Disuse

Levine S., Biswas C., Dierov J., Barsotti R., Shrager J. B. , Taitan Nguyen T. N. , ...Daha Fazla

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, cilt.183, ss.483-490, 2011 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 183 Konu: 4
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1164/200910-1487oc
  • Dergi Adı: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
  • Sayfa Sayıları: ss.483-490

Özet

Rationale: Patients on mechanical ventilation who exhibit diaphragm inactivity for a prolonged time (case subjects) develop decreases in diaphragm force-generating capacity accompanied by diaphragm myofiber atrophy.