Supporting Roles of Platelet Thrombospondin-1 and CD36 in Thrombus Formation on Collagen

Kuijpers, Marijke; de Witt, Susanne; Nergiz-Unal, REYHAN; van Kruchten, Roger; Korporaal, Suzanne; Verhamme, Peter; Febbraio, Maria; Tjwa, Marc; Voshol, Peter; Hoylaerts, Marc; Cosemans, Judith; Heemskerk, Johan

doi:10.1161/atvbaha.113.302917

Supporting Roles of Platelet Thrombospondin-1 and CD36 in Thrombus Formation on Collagen

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Kuijpers M. J. E., de Witt S., Nergiz-Unal R., van Kruchten R., Korporaal S. J. A., Verhamme P., ...More

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, vol.34, no.6, pp.1187-1192, 2014 (SCI-Expanded)

Publication Type: Article / Article
Volume: 34 Issue: 6
Publication Date: 2014
Doi Number: 10.1161/atvbaha.113.302917
Journal Name: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.1187-1192
Hacettepe University Affiliated: Yes

Abstract

Objective Platelets abundantly express the membrane receptor CD36 and store its ligand thrombospondin-1 (TSP1) in the -granules. We investigated whether released TSP1 can support platelet adhesion and thrombus formation via interaction with CD36.