JAK1/2 inhibition with baricitinib in the treatment of autoinflammatory interferonopathies

Sanchez, Gina; Reinhardt, Adam; Ramsey, Suzanne; Wittkowski, Helmut; Hashkes, Philip; Berkun, Yackov; Schalm, Susanne; Murias, Sara; Dare, Jason; Brown, Diane; Stone, Deborah; Gao, Ling; Klausmeier, Thomas; Foell, Dirk; De Jesus, Adriana; Chapelle, Dawn; Kim, Hanna; Dill, Samantha; Colbert, Robert; Failla, Laura; Kost, Bahar; O'Brien, Michelle; Reynolds, James; Folio, Les; Calvo, Katherine; Paul, Scott; Weir, Nargues; Brofferio, Alessandra; Soldatos, Ariane; Biancotto, Angelique; Cowen, Edward; Digiovanna, John; Gadina, Massimo; Lipton, Andrew; Hadigan, Colleen; Holland, Steven; Fontana, Joseph; Alawad, Ahmad; Brown, Rebecca; Rother, Kristina; Heller, Theo; Brooks, Kristina; Kumar, Parag; Brooks, Stephen; Waldman, Meryl; Singh, Harsharan; Nickeleit, Volker; Silk, Maria; Prakash, Apurva; Janes, Jonathan; ÖZEN, SEZA; Wakim, Paul; Brogan, Paul; Macias, William; Goldbach-Mansky, Raphaela

doi:10.1172/jci98814

JAK1/2 inhibition with baricitinib in the treatment of autoinflammatory interferonopathies

Sanchez G. A. M., Reinhardt A., Ramsey S., Wittkowski H., Hashkes P. J., Berkun Y., ...Daha Fazla

JOURNAL OF CLINICAL INVESTIGATION, cilt.128, sa.7, ss.3041-3052, 2018 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 128 Sayı: 7
Basım Tarihi: 2018
Doi Numarası: 10.1172/jci98814
Dergi Adı: JOURNAL OF CLINICAL INVESTIGATION
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.3041-3052
Hacettepe Üniversitesi Adresli: Evet

Özet

BACKGROUND. Monogenic IFN-mediated autoinflammatory diseases present in infancy with systemic inflammation, an IFN response gene signature, inflammatory organ damage, and high mortality. We used the JAK inhibitor baricitinib, with IFN-blocking activity in vitro, to ameliorate disease.