Reperfusion-induced oxidative/nitrative injury to neurovascular unit after focal cerebral ischemia

Gursoy-Ozdemir Y., Can A., Dalkara T.

STROKE, vol.35, no.6, pp.1449-1453, 2004 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 35 Issue: 6
  • Publication Date: 2004
  • Doi Number: 10.1161/01.str.0000126044.83777.f4
  • Title of Journal : STROKE
  • Page Numbers: pp.1449-1453


Background and Purpose-Use of thrombolysis in stroke is limited by a short therapeutic window because delayed reperfusion may cause brain hemorrhage and edema. Available evidence suggests a role for superoxide, NO, and peroxynitrite in reperfusion-induced injury. However, depending on their cellular origin and interactions between them, these molecules may exert protective or deleterious actions, neither of which is characterized in the intact brain.