New thiazolo[4,5-d]pyrimidine derivatives as potential antimicrobial agents


Urgun H., Balkan A., Ozalp M.

ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH, cilt.50, ss.1115-1119, 2000 (SCI İndekslerine Giren Dergi) identifier

  • Cilt numarası: 50 Konu: 12
  • Basım Tarihi: 2000
  • Dergi Adı: ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH
  • Sayfa Sayıları: ss.1115-1119

Özet

In this study, by starting from ethyl 4-amino-2,3-dihydro-3-phenyl-2-thioxothiazole-5-carboxylate (1), three compounds having 2,3-dihydro-3-phenyl-5-mercapto-6-alkyl/phenyl-2-thioxothiazolo [4,5-d]pyrimidin-7(6H)-one (2a-c) structure and their 5-(4'-nonsubstituted/-substituted benzoylmethyl)thio derivatives (3a-1) were synthesized. The antimicrobial activities of the synthesized compounds were investigated against some bacteria and fungi using the microdilution method. 2.3-Dihydro-3,6-diphenyl-5-(4'-bromobenzoylmethyl)thio-2-thioxothiazolo[4,5-d]pyrimidin-7(6H) one (3k) possessing remarkable activity against Gram-positive bacteria and yeast like fungi was found to be the most active compound in this series.