New thiazolo[4,5-d]pyrimidine derivatives as potential antimicrobial agents

Urgun H., Balkan A., Ozalp M.

ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH, vol.50, no.12, pp.1115-1119, 2000 (Peer-Reviewed Journal) identifier

  • Publication Type: Article / Article
  • Volume: 50 Issue: 12
  • Publication Date: 2000
  • Journal Indexes: Science Citation Index Expanded
  • Page Numbers: pp.1115-1119


In this study, by starting from ethyl 4-amino-2,3-dihydro-3-phenyl-2-thioxothiazole-5-carboxylate (1), three compounds having 2,3-dihydro-3-phenyl-5-mercapto-6-alkyl/phenyl-2-thioxothiazolo [4,5-d]pyrimidin-7(6H)-one (2a-c) structure and their 5-(4'-nonsubstituted/-substituted benzoylmethyl)thio derivatives (3a-1) were synthesized. The antimicrobial activities of the synthesized compounds were investigated against some bacteria and fungi using the microdilution method. 2.3-Dihydro-3,6-diphenyl-5-(4'-bromobenzoylmethyl)thio-2-thioxothiazolo[4,5-d]pyrimidin-7(6H) one (3k) possessing remarkable activity against Gram-positive bacteria and yeast like fungi was found to be the most active compound in this series.