Macrophage inflammatory protein-1 alpha: A link between innate immunity and familial mediterranean fever?

Dizdar O., Kalyoncu U., Karadag O., Akdogan A., Kiraz S., Ertenli I., ...More

CYTOKINE, vol.37, no.1, pp.92-95, 2007 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 37 Issue: 1
  • Publication Date: 2007
  • Doi Number: 10.1016/j.cyto.2006.12.005
  • Journal Name: CYTOKINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.92-95
  • Hacettepe University Affiliated: Yes


The aim of this study is to investigate the relationship between chemokines and the inflammation in Familial Mediterranean Fever (FMF). Forty-nine patients with FMF (41 in remission and 8 in acute attack period) and 20 healthy controls were included in the study. Serum levels of macrophage inflammatory protein-lot (MIP-1 alpha) were assessed in the patients and the controls, along with other parameters of disease activity, i.e., fibrinogen, C-reactive protein and erythrocyte sedimentation rate. Serum MIP-1 alpha levels of the patients with FMF in acute attack period were significantly higher than the patients in remission and healthy controls (p = 0.02 and p = 0.038, respectively). MIP-lot levels were weakly correlated with CRP (r = 0.32, p = 0.032) levels. MIP-lot may have a role in the pathogenesis of FMF attacks. MIP-1 alpha and other chemokines may constitute a link between the innate immune system and FMF. (C) 2006 Elsevier Ltd. All rights reserved.