MEFV mutations in systemic onset juvenile idiopathic arthritis


Ayaz N. A. , ÖZEN S., BİLGİNER Y., Erguven M., Taskiran E., YILMAZ E., ...More

RHEUMATOLOGY, vol.48, no.1, pp.23-25, 2009 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 48 Issue: 1
  • Publication Date: 2009
  • Doi Number: 10.1093/rheumatology/ken409
  • Journal Name: RHEUMATOLOGY
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.23-25
  • Keywords: Familial Mediterranean fever, Systemic onset juvenile idiopathic arthritis, Mediteranean fever, Mutation, FAMILIAL MEDITERRANEAN FEVER, GENE, PREVALENCE, DISEASE, FREQUENCY, PYRIN, FMF

Abstract

Objectives. Autoinflammatory diseases constitute a large spectrum of monogenic diseases like FMF or cryopyrin-associated periodic syndromes (CAPS) and complex genetic trait diseases such as systemic onset juvenile idiopathic arthritis (SoJIA). An increased rate of MEFV mutations has been shown among patients with PAN and HSP, in populations where FMF is frequent. The aim of the study is to search for MEFV mutations in our patients with SoJIA and see whether these mutations had an effect on disease course or complications.