The effects of myasthenic immunoglobulins on neuromuscular transmission and thymus histology in mice


DALKARA T., ONUR M. R., Ruacan Ş. A., Topaktaş S.

Neurology, vol.33, no.10, pp.1356-1359, 1983 (Scopus) identifier identifier

  • Publication Type: Article / Article
  • Volume: 33 Issue: 10
  • Publication Date: 1983
  • Doi Number: 10.1212/wnl.33.10.1356
  • Journal Name: Neurology
  • Journal Indexes: Scopus
  • Page Numbers: pp.1356-1359
  • Hacettepe University Affiliated: Yes

Abstract

An autoimmune reaction to the endplate acetylcholine receptor (AChR) is thought to be responsible for the muscular weakness of myasthenia gravis (MG). However, the significance of antithymic antibodies and the thymic AChR-like protein is still uncertain. We transferred immunoglobulins (Igs) from patients with MG to mice. Thymitis was observed in 12 of 14 mice, and miniature endplate potential amplitudes were reduced in 8. Control mice showed none of these abnormalities. Immunofluorescence examination failed to reveal the binding of human IgG, IgM, or IgA to the thymic tissue. Our findings support the hypothesis that antithymic antibodies may alter thymic histology. © 1983 American Academy of Neurology.