Detection of O6-methylguanine-DNA methyltransferase gene promoter region methylation pattern using pyrosequencing and the effect of methylation pattern on survival, recurrence, and chemotherapy sensitivity in patients with laryngeal cancer

Celebi, Ozlem; Tezel, Gaye; Hosal, ALİ; CENGİZ, MUSTAFA; GÜLLÜ, İBRAHİM; HAYRAN, KADİR

doi:10.1016/j.prp.2016.02.022

Detection of O6-methylguanine-DNA methyltransferase gene promoter region methylation pattern using pyrosequencing and the effect of methylation pattern on survival, recurrence, and chemotherapy sensitivity in patients with laryngeal cancer

Atıf İçin Kopyala

Celebi O. O., Tezel G. G., Hosal A. S., CENGİZ M., GÜLLÜ İ. H., HAYRAN K. M.

PATHOLOGY RESEARCH AND PRACTICE, cilt.212, sa.5, ss.456-462, 2016 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 212 Sayı: 5
Basım Tarihi: 2016
Doi Numarası: 10.1016/j.prp.2016.02.022
Dergi Adı: PATHOLOGY RESEARCH AND PRACTICE
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.456-462
Hacettepe Üniversitesi Adresli: Evet

Özet

Aim: To determine the methylation pattern of the promoter region of the O6-methylguanine-DNA methyltransferase (MGMT) gene in laryngeal cancer and normal laryngeal mucosa samples using pyrosequencing, and to determine the relationship between the methylation pattern of MGMT, and tumor stage, survival, recurrence, and chemosensitivity in patients with laryngeal cancer.