Detection of O6-methylguanine-DNA methyltransferase gene promoter region methylation pattern using pyrosequencing and the effect of methylation pattern on survival, recurrence, and chemotherapy sensitivity in patients with laryngeal cancer


Celebi O. O. , Tezel G. G. , Hosal A. S. , CENGİZ M. , GÜLLÜ İ. H. , HAYRAN K. M.

PATHOLOGY RESEARCH AND PRACTICE, cilt.212, ss.456-462, 2016 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 212 Konu: 5
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1016/j.prp.2016.02.022
  • Dergi Adı: PATHOLOGY RESEARCH AND PRACTICE
  • Sayfa Sayıları: ss.456-462

Özet

Aim: To determine the methylation pattern of the promoter region of the O6-methylguanine-DNA methyltransferase (MGMT) gene in laryngeal cancer and normal laryngeal mucosa samples using pyrosequencing, and to determine the relationship between the methylation pattern of MGMT, and tumor stage, survival, recurrence, and chemosensitivity in patients with laryngeal cancer.