Detection of O6-methylguanine-DNA methyltransferase gene promoter region methylation pattern using pyrosequencing and the effect of methylation pattern on survival, recurrence, and chemotherapy sensitivity in patients with laryngeal cancer

Celebi, Ozlem; Tezel, Gaye; Hosal, ALİ; CENGİZ, MUSTAFA; GÜLLÜ, İBRAHİM; HAYRAN, KADİR

doi:10.1016/j.prp.2016.02.022

Detection of O6-methylguanine-DNA methyltransferase gene promoter region methylation pattern using pyrosequencing and the effect of methylation pattern on survival, recurrence, and chemotherapy sensitivity in patients with laryngeal cancer

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Celebi O. O., Tezel G. G., Hosal A. S., CENGİZ M., GÜLLÜ İ. H., HAYRAN K. M.

PATHOLOGY RESEARCH AND PRACTICE, vol.212, no.5, pp.456-462, 2016 (SCI-Expanded)

Publication Type: Article / Article
Volume: 212 Issue: 5
Publication Date: 2016
Doi Number: 10.1016/j.prp.2016.02.022
Journal Name: PATHOLOGY RESEARCH AND PRACTICE
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.456-462
Hacettepe University Affiliated: Yes

Abstract

Aim: To determine the methylation pattern of the promoter region of the O6-methylguanine-DNA methyltransferase (MGMT) gene in laryngeal cancer and normal laryngeal mucosa samples using pyrosequencing, and to determine the relationship between the methylation pattern of MGMT, and tumor stage, survival, recurrence, and chemosensitivity in patients with laryngeal cancer.