Acrolein-mediated neurotoxicity in growing Wistar male rats

SELMANOĞLU G., Ozgun G. M., KARACAOĞLU E.

PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, cilt.149, ss.37-43, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 149
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1016/j.pestbp.2018.05.006
  • Dergi Adı: PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.37-43
  • Anahtar Kelimeler: Acrolein, Neurotoxicity, Histopathology, Neurofilament, Rat, ALZHEIMERS-DISEASE, NEURODEGENERATIVE DISEASES, MOLECULAR-MECHANISMS, MULTIPLE-SCLEROSIS, PROTEIN, RELEVANCE, ALDEHYDE, CULTURES, BRAIN, CELLS
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Acrolein is an environmental and food contaminant widely produced by thermal processed organic compounds. It can be used as a biocide and is known to be generated endogenously by lipid peroxidation. This study was designed for evaluating acrolein toxicity in the context of GFAP, MBP, neurofilaments and histological examination of brain tissues and also hematological paremeters in pubertal male rats. 3-4 weeks aged Wistar male rats were exposed to 0.5, 1 and 2 mg/kg/day acrolein for 90 days. According to acrolein exposure results, slight changes observed in hematological parameters, however no significant differences were observed in GFAP and MBP. Unlikely, acrolein caused several histopathological changes in brain tissues as well as neurofilament accumulation. It may be concluded that acrolein might contribute to formation of neurodegenerative disorders.