4-Difluoro-substituted phenyl-5-oxo-hexahydroquinoline derivatives and their effects on calcium channels


Simsek R. , Gunduz M. G. , Sirmagul B., Safak C. , Erol K., Linden A.

ARZNEIMITTELFORSCHUNG-DRUG RESEARCH, cilt.56, ss.529-534, 2006 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 56 Konu: 7
  • Basım Tarihi: 2006
  • Dergi Adı: ARZNEIMITTELFORSCHUNG-DRUG RESEARCH
  • Sayfa Sayıları: ss.529-534

Özet

Twenty new methyl(ethyl) 2,6,6- or 2,7,7-trimethyl-5-oxo-4-(disubstituted phenyl)1,4,5,6,7,8-hexahydroquinoline-3-carboxylates and ten new N,N- diethyl-2,6,6- or 2,7,7-trimethyl-5-oxo-4-(disubstituted phenyl)-1,4,5,6,7,8-hexahydroquinoline-3-carboxamide derivatives have been synthesised and screened for their calcium channel antagonistic activity. The compounds were synthesised by the Hantzsch reaction. Calcium antagonistic activities of the compounds were determined by the tests performed on isolated rat ileum and rat thoracic artery.