Inflammatory bowel disease-like colitis in a young Turkish child with glycogen storage disease type 1b and elevated platelet count
TURKISH JOURNAL OF PEDIATRICS, vol.47, no.2, pp.180-182, 2005 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 47 Issue: 2
- Publication Date: 2005
- Journal Name: TURKISH JOURNAL OF PEDIATRICS
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.180-182
- Keywords: glycogenosis, inflammatory bowel disease, neutropenia, platelet, COLONY-STIMULATING FACTOR, NEUTROPHIL DYSFUNCTION, IB
- Hacettepe University Affiliated: Yes
Abstract
Inflammatory bowel disease (IBD)-like colitis is a known entity in glycogen storage disease (GSD) type 1b patients. The mean age of the reported cases with IBD-like colitis was 12 +/- 5 years, and all had absolute neutrophil count (ANC) less than 1,000 cells/mu l. We report a three-year-old girl with GSD type 1b that was dignosed by mutation analysis. The patient was hospitalized with fever, diarrhea, and perioral and anal ulcers. Colonoscopy was performed and IBD-like colitis was diagnosed. The patient had elevated platelet count beyond the age of three months, but IBD-like colitis was diagnosed at three years of age. An elevated platelet count may be a warning sign for the IBD-like colitis in young patients with GSD type 1b.