In vitro activity of terbinafine and itraconazole against Aspergillus species isolated from otomycosis

Karaarslan A., Arikan S., Ozcan M., Ozcan K.

MYCOSES, cilt.47, sa.7, ss.284-287, 2004 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 47 Sayı: 7
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1111/j.1439-0507.2004.00988.x
  • Dergi Adı: MYCOSES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.284-287
  • Hacettepe Üniversitesi Adresli: Hayır

Özet

The minimum inhibitory concentrations (MIC, mug ml(-1)) of itraconazole and terbinafine against overall 34 Aspergillus isolates from the external ear canals with otomycosis have been determined with M38-P microdilution method suggested by National Committee for Clinical Laboratory Standards (NCCLS). MIC intervals in 48 h determined by taking MIC-2 value of itraconazole (the lowest drug concentration causing 50% inhibition of visible fungal growth) and MIC-0 value of terbinafine (the lowest drug concentration causing 100% inhibition of visible fungal growth) as a basis have been found as follows: 0.125-1 and 0.06-0.5 mug ml(-1) for A. niger (22 strains), 0.06-0.25 and 0.06-0.125 mug ml(-1) for A. flavus (10 strains), 0.125 and 0.125-0.5 mug ml(-1) for A. terreus (two strains). It has been observed that both of the antifungal agents showed an in vitro activity against all Aspergillus species tested.