In vitro activity of terbinafine and itraconazole against Aspergillus species isolated from otomycosis

Karaarslan A., Arikan S., Ozcan M., Ozcan K.

MYCOSES, vol.47, no.7, pp.284-287, 2004 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 47 Issue: 7
  • Publication Date: 2004
  • Doi Number: 10.1111/j.1439-0507.2004.00988.x
  • Journal Name: MYCOSES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.284-287
  • Hacettepe University Affiliated: No


The minimum inhibitory concentrations (MIC, mug ml(-1)) of itraconazole and terbinafine against overall 34 Aspergillus isolates from the external ear canals with otomycosis have been determined with M38-P microdilution method suggested by National Committee for Clinical Laboratory Standards (NCCLS). MIC intervals in 48 h determined by taking MIC-2 value of itraconazole (the lowest drug concentration causing 50% inhibition of visible fungal growth) and MIC-0 value of terbinafine (the lowest drug concentration causing 100% inhibition of visible fungal growth) as a basis have been found as follows: 0.125-1 and 0.06-0.5 mug ml(-1) for A. niger (22 strains), 0.06-0.25 and 0.06-0.125 mug ml(-1) for A. flavus (10 strains), 0.125 and 0.125-0.5 mug ml(-1) for A. terreus (two strains). It has been observed that both of the antifungal agents showed an in vitro activity against all Aspergillus species tested.