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INDIAN JOURNAL OF HEMATOLOGY AND BLOOD TRANSFUSION, 2025 (SCI-Expanded)
This study aimed to investigate the factors that influence chemotherapy-induced nausea, vomiting, and alterations in taste experienced by non-Hodgkin lymphoma. This cross-sectional study recruited 133 non-Hodgkin lymphomas from January 2022 to December 2023. Patients completed the Chemotherapy Induced Taste Alteration Scale (CITAS) and Rhodes Index of Nausea, Vomiting, and Retching (RINVR). A multiple linear regression model was used to investigate the factors that influence taste alterations in chemotherapy-induced nausea and vomiting. The factors influencing the subgroups of CITAS and RINVR were identified using ANOVA and multinomial logistic regression analyses. The regression model established to determine the effect of basic taste alteration, loss of appetite symptoms, nausea vomiting, age, and vomiting distress was statistically significant and explained 84.1% of the change. Via multiple linear regression analysis, we identified substantial factors in basic taste alteration associated with loss of appetite symptoms [(95%CI: 0.083-0.123); P = 0.000], nausea-vomiting[(95%CI: 0.001-0.096); P = 0.045], age [(95%CI: - 0.101-0.027); P = 0.001], vomiting distress [(95%CI: - 2.114-0.865); P = 0.001]. According to the model, a 1-unit change in basic taste alteration caused a 0.189-unit change in nausea and vomiting.Taste alteration statistically significantly affected symptoms of loss of appetite, nausea and vomiting, age, and vomiting distress. The results will provide deep insights into developing effective intervention strategies to address this common issue of non-Hodgkin lymphoma.