Human activities and agriculture have had direct and indirect effects on the rates of contamination of groundwater in the Incesu-Dokuzpinar spring area. Direct effects include dissolution and transport of excess quantities of fertilizers with associated materials and hydrological alterations related to irrigation and drainage. Indirect effects may include changes in water-rock reactions in soils and aquifers caused by increased concentrations of dissolved oxidants, protons, and major ions. Agricultural activities have directly or indirectly affected the concentrations of a large number of inorganic chemicals in groundwater, for example NO3, N-2, Cl, SO42, H+, K, Mg, Ca, Fe, Cu, B, Pb, and Zn, as well as a wide variety of pesticides and other organic compounds. For reactive contaminants like NO3, it is recommended that a combination of hydrochemical and environmental-tracer analytical approaches might be required to resolve changing inputs from subsequent alterations as causes of concentration gradients in groundwater. The water type of Dokuzpinar springs is mainly Na-Mg-Ca-Cl-HCO3. Note that the water types of the springs were directly related to the hydrogeochemical properties of outcrops at the study area. Thus, the high concentration of Ca2+ and HCO3 is mainly related to the high CO2 contents in the marbles, whereas the high Na concentration arises from the existing syenite, volcanic ash, basalt, and clay units, although the Incesu-Dokuzpinar springs cover most of the drinking and irrigation water demands of this area. The high concentrations of NO3 and NaCl show that the area around the springs is continuously being contaminated by untreated sewage and agricultural wastes, especially during dry periods. Therefore, this approach is based on the vulnerability studies of the catchment area, determination of the transfer time of the pollutant, and the water-bearing formations of Incesu-Dokuzpinar springs. Vulnerability in this study is defined as the intrinsic hydrogeochemical characteristics of an aquifer, which may show the sensitivity of groundwater to be contaminated by different human activities.